CBD’s Role in Inflammation
Adenosine is a chemical compound that plays a role in inhibiting the inflammatory actions of the body. Adenosine receptors in the heart also help to modulate blood flow. The graph below shows how cellular uptake of adenosine was decreased in cells that were pretreated with varying amounts of CBD and THC.
The 2006 study “Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression” concluded that both molecules inhibit adenosine uptake. By inhibiting adenosine uptake, CBD (and, less potently, THC) could play a therapeutic role in pain and inflammation.
“These studies demonstrate that CBD has the ability to enhance adenosine signaling through inhibition of uptake and provide a non-cannabinoid receptor mechanism by which CBD can decrease inflammation.”
By helping to reduce excess inflammation, CBD could play a role in maintaining healthy immune function. This is an area of particular interest to athletes and all those seeking an alternative to anti-inflammatory pharmaceuticals.
Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression - Proceedings of the National Academy of Sciences of the United States of America, May 2006, Volume 103, Number 20, Pages 7895–7900